This condition causes white, wrinkled skin changes in the labia and in the perianal region, and it usually responds Itch bumps in the area around anus a 6- to 8-week dose of topical steroids. Find a sexual health clinic. Mayo Clinic Marketplace Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Certain long-term health conditions can contribute to anal itching and inflammation in a variety of ways. Community content from Health Unlocked. Anti-viral medication can help keep herpes under control, while treating anal warts may require topical creams, cryotherapy, or even surgery. Certain foods can also contribute to diarrhea or anal leakage, which can make it more difficult to wipe thoroughly and can cause irritation and itching in itself.